Thiamine
Administration
- Dosage Forms: 50,100,250,500mg
- Routes of Administration: IM, IV
- Im or IV routres require: Intradermal skin test before use if hypersensitivity risk
- Common Trade Names: Vitamin B1
Adult Dosing
- Beriberi
- 10-20mg IM tid x 2wk
- Then 5-30mg PO QD x1mo
- 10-20mg IM tid x 2wk
- Wet beriberi with CHF
- 10-30mg IV tid
- Wernicke's encephalopathy
- High-dose parenteral regimen: 500mg IV TID x 2 days
- Then 250mg IM/IV QD x 5 days
- High-dose parenteral regimen: 500mg IV TID x 2 days
Pediatric Dosing
Special Populations
- Pregnancy Rating: A (according to dietary reference intake)
- Lactation risk: Safe
Renal Dosing
Not defined
Hepatic Dosing
Not defined
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- anaphylaxis
- angioedema
- cyanosis
Common
- injection site pain
- pruritus
- warmth sensation
- urticaria
Pharmacology
- Half-life: Unknown
- Metabolism: Liver, CYP450, Unknown
- Excretion: Urine
Mechanism of Action
Physiologic cofactor
Comments
Indications by Condition
The following table is automatically generated from disease/condition pages across WikEM.
| Indication | Dose | Context | Route | Population |
|---|---|---|---|---|
| Beriberi | 50-100mg IV/IM daily x 7-14 days, then 10mg PO daily until recovery | Thiamine replacement | IV/IM | Adult |
| Ethanol withdrawal | 100 mg PO daily | Vitamin prophylaxis | PO | Adult |
| Ethylene glycol toxicity | 100 mg q6hr x2 days | Decrease oxalate production | IV | Adult |
| Wernicke-Korsakoff syndrome | 500mg IV over 30min TID x 2-3 days, then 250mg IV/IM daily x 3-5 days, then 100mg PO daily | Treatment dose for confirmed/suspected Wernicke encephalopathy | IV | Adult |