Template:Acute cystitis antibiotics

===Outpatient=== Women, Uncomplicated

• Nitrofurantoin ER 100mg BID x 5d, OR
• TMP/SMX DS (160/800mg) 1 tab BID x 3d (Females) x7days (Males), OR
• Cephalexin 250mg QID x 5d, OR
• Ciprofloxacin 250mg BID x3d
  • Avoid using fluoroquinolone for the first-line treatment of uncomplicated urinary tract infections (UTIs) in women.
• Fosfomycin 3 g PO once
  • Lower clinical and microbiologic success compared to nitrofurantoin TID for 5 days

Women, Complicated

• Ciprofloxacin 500mg BID x10-14d, OR
• Cefpodoxime 200 mg BID x10-14d

Women, Concern for Urethritis

• Ceftriaxone 250mg IM x1 AND azithromycin 1gm PO x1 AND nitrofurantoin ER 100mg BID x5d, OR
• Levofloxacin 500mg QD x 14d (covers urinary pathogens, GC, and chlamydia)
  • GC resistance to fluoroquinolones is increasing

Men

• Ciprofloxacin 500mg BID x10-14d, OR
• Cefpodoxime 200 mg BID x10-14d

===Inpatient Options=== *Ciprofloxacin 400mg IV q12hr, OR

• Ceftriaxone 1gm IV QD, OR
• Cefotaxime 1-2gm IV q8hr, OR
• Gentamicin 3mg/kg/day divided q8hr +/- ampicillin 1–2 gm q4hr, OR
• Piperacillin/Tazobactam 3.375 gm IV q6hr, OR
• Cefepime 2gm IV q8hr, OR
• Imipenem/Cilastatin 500mg IV q8hr
• Cefotetan 500 mg IM/IV q12h

Pediatric

• TMP/SMX 6-12mg/kg/day (TMP) PO divided BID x 7-10 days
• Cephalexin 25-50mg/kg/day PO divided q6-8h x 7-10 days (max 500mg/dose)
• Nitrofurantoin 5-7mg/kg/day PO divided q6h x 7-10 days; avoid in infants <1 month
• Cefpodoxime 10mg/kg/day PO divided BID (max 200mg/dose)
• Cefixime 8mg/kg/day PO daily (max 400mg)

Pediatric Inpatient

• Ceftriaxone 50-75mg/kg IV daily (max 2g)
• Cefotaxime 50mg/kg IV q8hrs (max 2g/dose)
• Gentamicin 2.5mg/kg IV q8hrs +/- Ampicillin 50mg/kg IV q6hrs