Naproxen

Administration

• Type: NSAID
• Dosage Forms: 250mg, 500mg
• Routes of Administration: PO
• Common Trade Names: Aleve

Adult Dosing

• 500mg PO BID OR 250mg q6-8h

Pediatric Dosing

• 5mg/kg BID

Special Populations

• Pregnancy Rating: C
• Lactation risk: infant risk minimal

Renal Dosing

• Adult: Not recommended if CrCl <30
• Pediatric:

Hepatic Dosing

• Adult: use lowest effective dose
• Pediatric:

Contraindications

• Allergy to class/drug
• peri-CABG

Adverse Reactions

Serious

• GI bleed, gastric ulcer
• Nephrotoxicity
• Angioedema
• Bronchospasm
• CHF, pulmonary edema
• Thrombocytopenia, aplastic anemia, hemolytic anemia, agranulocytosis
• Vasculitis
• SJS/TEN
• Hepatotoxicity (hepatitis, liver failure)
• Aseptic meningitis, seizure

Common

• Nausea, heartburn, constipation
• Edema
• Ecchymosis
• Headache
• Ototoxicity

Pharmacology

• Half-life: 12-17 hours
• Metabolism:
• Excretion: Renal

Mechanism of Action

• NSAID

Indications by Condition

The following table is automatically generated from disease/condition pages across WikEM.

Indication	Dose	Context	Route	Population
Acute pain management	250 mg PO q6-8h or 500-1000 mg PR q6-8h	Non-opioid analgesic (NSAID)	PO/PR	Adult
Gout and pseudogout	500mg BID x 3-7 days	First-line NSAID option for acute gout	PO	Adult

See Also

• NSAIDs
• NSAID toxicity