Diferencia entre revisiones de «Thiamine»
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==Adult Dosing== | ==Adult Dosing== | ||
*Beriberi | *[[Beriberi]] | ||
**10- | **10-20mg IM tid x 2wk | ||
***Then 5- | ***Then 5-30mg PO QD x1mo | ||
*Wet beriberi | *Wet beriberi with CHF | ||
**10- | **10-30mg IV tid | ||
*Wernicke encephalopathy | *[[Wernicke-Korsakoff syndrome|Wernicke's encephalopathy]] | ||
** | **High-dose parenteral regimen: 500mg IV TID x 2 days | ||
***Then | ***Then 250mg IM/IV QD x 5 days | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: A (according to dietary reference intake) | ||
*[[Lactation risk categories|Lactation risk]]: | *[[Lactation risk categories|Lactation risk]]: Safe | ||
===Renal Dosing=== | ===Renal Dosing=== | ||
Not defined | |||
===Hepatic Dosing=== | ===Hepatic Dosing=== | ||
Not defined | |||
==Contraindications== | ==Contraindications== | ||
| Línea 34: | Línea 33: | ||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*anaphylaxis | |||
*angioedema | |||
*cyanosis | |||
===Common=== | ===Common=== | ||
*injection site pain | |||
*pruritus | |||
*warmth sensation | |||
*urticaria | |||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: Unknown | ||
*Metabolism: | *Metabolism: Liver, CYP450, Unknown | ||
*Excretion: | *Excretion: Urine | ||
==Mechanism of Action== | ==Mechanism of Action== | ||
Physiologic cofactor | |||
==Comments== | ==Comments== | ||
==Indications by Condition== | |||
''The following table is automatically generated from disease/condition pages across WikEM.'' | |||
{{#ask:[[Has DrugName::Thiamine]] | |||
|?Has Indication=Indication | |||
|?Has Dose=Dose | |||
|?Has Context=Context | |||
|?Has Route=Route | |||
|?Has Population=Population | |||
|format=table | |||
|headers=plain | |||
|mainlabel=- | |||
|sort=Has Indication | |||
|limit=50 | |||
}} | |||
==See Also== | ==See Also== | ||
| Línea 50: | Línea 74: | ||
==References== | ==References== | ||
*[https://online.epocrates.com/drugs/188810/vitamin-B1-common-name/Monograph Epocrates: Vitamin B1] | |||
<references/> | <references/> | ||
[[Category: | [[Category:Pharmacology]] | ||
[[Category:FEN]] | |||
Revisión actual - 21:56 20 mar 2026
Administration
- Dosage Forms: 50,100,250,500mg
- Routes of Administration: IM, IV
- Im or IV routres require: Intradermal skin test before use if hypersensitivity risk
- Common Trade Names: Vitamin B1
Adult Dosing
- Beriberi
- 10-20mg IM tid x 2wk
- Then 5-30mg PO QD x1mo
- 10-20mg IM tid x 2wk
- Wet beriberi with CHF
- 10-30mg IV tid
- Wernicke's encephalopathy
- High-dose parenteral regimen: 500mg IV TID x 2 days
- Then 250mg IM/IV QD x 5 days
- High-dose parenteral regimen: 500mg IV TID x 2 days
Pediatric Dosing
Special Populations
- Pregnancy Rating: A (according to dietary reference intake)
- Lactation risk: Safe
Renal Dosing
Not defined
Hepatic Dosing
Not defined
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- anaphylaxis
- angioedema
- cyanosis
Common
- injection site pain
- pruritus
- warmth sensation
- urticaria
Pharmacology
- Half-life: Unknown
- Metabolism: Liver, CYP450, Unknown
- Excretion: Urine
Mechanism of Action
Physiologic cofactor
Comments
Indications by Condition
The following table is automatically generated from disease/condition pages across WikEM.
| Indication | Dose | Context | Route | Population |
|---|---|---|---|---|
| Beriberi | 50-100mg IV/IM daily x 7-14 days, then 10mg PO daily until recovery | Thiamine replacement | IV/IM | Adult |
| Ethanol withdrawal | 100 mg PO daily | Vitamin prophylaxis | PO | Adult |
| Ethylene glycol toxicity | 100 mg q6hr x2 days | Decrease oxalate production | IV | Adult |
| Wernicke-Korsakoff syndrome | 500mg IV over 30min TID x 2-3 days, then 250mg IV/IM daily x 3-5 days, then 100mg PO daily | Treatment dose for confirmed/suspected Wernicke encephalopathy | IV | Adult |