Diferencia entre revisiones de «Sodium nitrite toxicity»
(Created page with "==Background== ==Clinical Features== ==Differential Diagnosis== ==Evaluation== ===Workup=== ===Diagnosis=== ==Management== ==Disposition== ==See Also== ==External Links== ==References== <references/>") |
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==Background== | ==Background== | ||
*Sodium Nitrite is an inorganic compound composed of a sodium (Na) bonded to a nitrite (NO2) group<ref name="wikipedia">https://en.wikipedia.org/wiki/Sodium_nitrite</ref> | |||
**High-purity sodium nitrite is a highly water-soluble, yellowish-white powder<ref name="wikipedia"/> | |||
== | **It has many uses across multiple industries, including as a food additive | ||
**[[Sodium nitrite]] also has some medical use as an antidote to certain toxidromes. | |||
*Recent toxicology and suicidology literature has described a trend of suicides by poisoning with sodium nitrite.<ref name="Nursing">Smith EM. Sodium nitrite suicide and social media influence. Nursing. 2023;53(12):44-47. doi:10.1097/01.NURSE.0000991568.99431.13</ref><ref name="SocialMedia">Smith EM. Sodium nitrite suicide and social media influence. Nursing. 2023;53(12):44-47. doi:10.1097/01.NURSE.0000991568.99431.13</ref><ref name="SysReview">Mazzini E, Feola A, Fracassi I, et al. Suicide by sodium nitrite ingestion: a systematic review. Forensic Sci Med Pathol. Published online August 30, 2025. doi:10.1007/s12024-025-01066-9</ref><ref name="Surveillance">Bloom J, Sharpe A, Nulman S, et al. Comparing Confirmed Sodium Nitrite Suicide Deaths With Poison Center Surveillance Estimates. JAMA Netw Open. 2024;7(9):e2434192. Published 2024 Sep 3. doi:10.1001/jamanetworkopen.2024.34192</ref><ref name="Reporting">Khan H, Barber C, Azrael D. Suicide by sodium nitrite poisoning: Findings from the National Violent Death Reporting System, 2018-2020. Suicide Life Threat Behav. 2024;54(2):310-316. doi:10.1111/sltb.13043</ref><ref name="DualReport">Yoon JC, Kim SE. Suicide attempt using sodium nitrite ordered on the internet: Two case reports. Medicine (Baltimore). 2022;101(28):e29355. Published 2022 Jul 15. doi:10.1097/MD.0000000000029355</ref><ref name="InternetOrder">Loiseau M, Matheux A, Sabini S, et al. Suicide of an adolescent girl with sodium nitrite ordered on the internet. J Forensic Sci. 2023;68(6):2200-2204. doi:10.1111/1556-4029.15350</ref> | |||
**It may be a component of "[[Suicide kits]]" which can be ordered online. | |||
*Within the body, sodium nitrite is a powerful oxidizer, causing severe methemoglobinemia | |||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
*Consider alternative causes of [[Methemoglobinemia]] | |||
===Diagnosis=== | ===Diagnosis=== | ||
*Clinical diagnosis of Sodium nitrite toxicity should be made based on presence of [[Methemoglobinemia]] and contextual clues suggesting suicidality or possible exposure to sodium nitrite | |||
==Management | ==Management and Disposition== | ||
*See [[Methemoglobinemia]] for general principles of medical management | |||
*Contact POISON CONTROL or consult toxicology for additional assistance | |||
*Consider behavioral health consultation for suicidality | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Revisión actual - 16:16 3 nov 2025
Background
- Sodium Nitrite is an inorganic compound composed of a sodium (Na) bonded to a nitrite (NO2) group[1]
- High-purity sodium nitrite is a highly water-soluble, yellowish-white powder[1]
- It has many uses across multiple industries, including as a food additive
- Sodium nitrite also has some medical use as an antidote to certain toxidromes.
- Recent toxicology and suicidology literature has described a trend of suicides by poisoning with sodium nitrite.[2][3][4][5][6][7][8]
- It may be a component of "Suicide kits" which can be ordered online.
- Within the body, sodium nitrite is a powerful oxidizer, causing severe methemoglobinemia
Differential Diagnosis
- Consider alternative causes of Methemoglobinemia
Diagnosis
- Clinical diagnosis of Sodium nitrite toxicity should be made based on presence of Methemoglobinemia and contextual clues suggesting suicidality or possible exposure to sodium nitrite
Management and Disposition
- See Methemoglobinemia for general principles of medical management
- Contact POISON CONTROL or consult toxicology for additional assistance
- Consider behavioral health consultation for suicidality
References
- ↑ 1.0 1.1 https://en.wikipedia.org/wiki/Sodium_nitrite
- ↑ Smith EM. Sodium nitrite suicide and social media influence. Nursing. 2023;53(12):44-47. doi:10.1097/01.NURSE.0000991568.99431.13
- ↑ Smith EM. Sodium nitrite suicide and social media influence. Nursing. 2023;53(12):44-47. doi:10.1097/01.NURSE.0000991568.99431.13
- ↑ Mazzini E, Feola A, Fracassi I, et al. Suicide by sodium nitrite ingestion: a systematic review. Forensic Sci Med Pathol. Published online August 30, 2025. doi:10.1007/s12024-025-01066-9
- ↑ Bloom J, Sharpe A, Nulman S, et al. Comparing Confirmed Sodium Nitrite Suicide Deaths With Poison Center Surveillance Estimates. JAMA Netw Open. 2024;7(9):e2434192. Published 2024 Sep 3. doi:10.1001/jamanetworkopen.2024.34192
- ↑ Khan H, Barber C, Azrael D. Suicide by sodium nitrite poisoning: Findings from the National Violent Death Reporting System, 2018-2020. Suicide Life Threat Behav. 2024;54(2):310-316. doi:10.1111/sltb.13043
- ↑ Yoon JC, Kim SE. Suicide attempt using sodium nitrite ordered on the internet: Two case reports. Medicine (Baltimore). 2022;101(28):e29355. Published 2022 Jul 15. doi:10.1097/MD.0000000000029355
- ↑ Loiseau M, Matheux A, Sabini S, et al. Suicide of an adolescent girl with sodium nitrite ordered on the internet. J Forensic Sci. 2023;68(6):2200-2204. doi:10.1111/1556-4029.15350