Diferencia entre revisiones de «Angiotensin II»
Sin resumen de edición |
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==Adult Dosing== | ==Adult Dosing== | ||
Septic or Distributive Shock | Septic or Distributive [[Shock]] | ||
*20 nanograms (ng)/kg/min. | *20 nanograms (ng)/kg/min. | ||
**Titrate as frequently as every 5 minutes by increments of up to 15 ng/kg/min as needed. <br /> | **Titrate as frequently as every 5 minutes by increments of up to 15 ng/kg/min as needed. <br /> | ||
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==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
* | *Thrombosis (13%) | ||
**DVT (4%) | **[[DVT]] (4%) | ||
*Thrombocytopenia (9%) | *Thrombocytopenia (9%) | ||
*Tachycardia (8.6%) | *Tachycardia (8.6%) | ||
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==Mechanism of Action== | ==Mechanism of Action== | ||
*Synthetic human angiotensin II which is a peptide hormone of the renin-angiotensin-aldosterone system (RAAS) that causes vasoconstriction and an increase in blood pressure | *Synthetic human angiotensin II which is a peptide hormone of the renin-angiotensin-aldosterone system (RAAS) that causes vasoconstriction and an increase in blood pressure | ||
*Increases | *Increases Aldosterone | ||
==Comments== | ==Comments== | ||
Revisión actual - 17:20 16 jun 2021
Administration
- Type: vasopressor
- Dosage Forms: Injection: 2.5 mg/mL and 5 mg/2 mL (2.5 mg/mL) in a vial
- Routes of Administration: IV
- Common Trade Names: GIAPREZA
Adult Dosing
Septic or Distributive Shock
- 20 nanograms (ng)/kg/min.
- Titrate as frequently as every 5 minutes by increments of up to 15 ng/kg/min as needed.
- Titrate as frequently as every 5 minutes by increments of up to 15 ng/kg/min as needed.
During the first 3 hours, the maximum dose should not exceed 80 ng/kg/min.
Maintenance dose should not exceed 40 ng/kg/min
Special Populations
Pregnancy Rating
- unkown
Lactation risk
- unknown
Renal Dosing
None
Hepatic Dosing
None
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Thrombosis (13%)
- DVT (4%)
- Thrombocytopenia (9%)
- Tachycardia (8.6%)
- Fungal infection (6.1%)
Common
Pharmacology
- Half-life: ~1 minute
- Metabolism: broken down by proteins in blood, RBC's, major organs
Mechanism of Action
- Synthetic human angiotensin II which is a peptide hormone of the renin-angiotensin-aldosterone system (RAAS) that causes vasoconstriction and an increase in blood pressure
- Increases Aldosterone
Comments
- Patient's on ACEi may have increased response to Angiotensin II
- Patient's on ARB's may have decreased response to Angiotensin II