Captopril

Administration

• Type: ACE-inhibitor
• Dosage Forms:
• Routes of Administration: Oral
• Common Trade Names:

Adult Dosing

• 6.25-150mg PO three times per day

Pediatric Dosing

Safety/efficacy not established in pediatric patients

Special Populations

• Pregnancy Rating: D
• Lactation risk: Infant risk minimal
• Renal dosing: Initial dose should be reduced, titrate in smaller increments

Contraindications

• Allergy to class/drug
• History of ACE-inhibitor induced angioedema

Adverse Reactions

Serious

• Angioedema
• Stevens-Johnson syndrome
• Agranulocytosis, neutropenia

Common

• Hypotension
• Hyperkalemia
• Cough
• Rash

Pharmacology

• Half-life: < 3 hours
• Metabolism:
• Excretion: Renal, dialzable

Mechanism of Action

• Inhibits angiotensin I-converting enzyme, blocks conversion of angiotensin I--> angiotensin II

See Also

• ACE-inhibitors