Carbamazepine toxicity
Revisión del 00:46 27 jun 2016 de Neil.m.young (discusión | contribs.) (Text replacement - "*Tintinalli" to "")
Background
- Has anticholinergic and antiepileptic effects
- Therapeutic concentration: 4-12
Clinical Features
- May be delayed and follow crescendo-decrescendo course (due to delayed GI motility)
- CNS
- Ataxia
- Nystagmus
- Coma
- Anticholinergic Toxicity
- CV
- Dysrhythmias are rare but may occur
- Wide QRS
- QT Prolongation
Diagnosis
- Levels do not accurately correlate w/ clinical severity
Treatment
- GI detox
- Activated Charcoal (if presents w/in 1hr of ingestion)
- Dialysis is effective (if needed)
Disposition
- Consider discharge for pt with decreasing levels (measured few hrs apart) and is asymptomatic