Neuromuscular blocking agents
Revisión del 22:45 25 jun 2016 de Neil.m.young (discusión | contribs.) (Text replacement - "==Sources==" to "==References==")
Background
- Non-depolarizing
- Competitively block binding of ACh to its receptors
- Depolarizing
- Depolarizing skeletal muscle fiber
- Persistent depolarization makes the muscle fiber resistant to further stimulation by ACh
Types
| Agent | Time to onset (seconds) | Duration (minutes) | Side effects |
|---|---|---|---|
| Non-Depolarizing | |||
| Succinylcholine | fasciculations, post-operative pain | ||
| Depolarizing | |||
| Vecuronium (Norcuron) | 60 | 30–40 | Few, may cause prolonged paralysis and promote muscarinic block |
| Rocuronium (Zemuron) | 75 | 45–70 | may promote muscarinic block |
| Pancuronium (Pavulon) | 90 | 180 or more |
|