Antipsychotic toxicity

Revisión del 20:27 1 ene 2012 de Jswartz (discusión | contribs.) (Created page with "==Background== *Toxicity results in blockade of some or all of the following receptors: **Dopamine - extrapyramidal symptoms **Alpha1 - orthostatic hypotension, reflex tachycardi...")
(difs.) ← Revisión anterior | Revisión actual (difs.) | Revisión siguiente → (difs.)

Background

  • Toxicity results in blockade of some or all of the following receptors:
    • Dopamine - extrapyramidal symptoms
    • Alpha1 - orthostatic hypotension, reflex tachycardia
    • Muscarinic - anticholinergic symptoms
    • Histamine - sedation


Clinical Features

  1. Extrapyramidal
    1. Acute dystonia
      1. Tongue protrusion, facial grimacing, trismus, oculogyric crisis
    2. Akathisia


Treatment

  1. Extrapyramidal
    1. Diphenhydramine 25-50mg IV/IM OR benztropine 1-2mg IV/IM
    2. Oral therapy with either of above meds should be continued for 2 weeks


See Also

Source

  • Tintinalli
Obtenido de «https://www.wikem.org/w/index.php?title=Antipsychotic_toxicity&oldid=7348»