Pruritic papular eruption of HIV

Background

  • Most common rash of HIV[1]
  • Presenting symptom of HIV in up to ~80% cases
  • 3x more common when CD4 count < 200
  • Up to 46% of HIV pts have this rash at some time of disease course
  • Diagnosis of exclusion

Clinical Features

  • Pruritic
  • Diffusely, symmetrically distributed rash
  • Discrete red bumps initially
  • Extremities/trunk > face
  • Mucous membrane sparing

Differential

Treatments

  • Initially topical steroids, emollients, PO antihistamines
  • UV phototherapy for refractory cases

Disposition

  • Outpatient dermatology f/u
  • Average time for recurrence of skin condition ~8 wks

References

  1. Cutaneous manifestations of HIV in the era of highly active antiretroviral therapy: an institutional urban clinic experience. Zancanaro PC et al. J Am Acad Dermatol. 2006 Apr;54(4):581-8.