Hirudins

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Background

  • Direct thrombin inhibitors
    • Examples: Hirudin, lepirudin, argatroban
  • Half-life is ~2hr

Indications

  1. HIT
  2. UA/NSTEMI/PCI

Complications

  1. Bleeding
    1. Majority of bleeding events occur at invasive sites
    2. No antidote available
    3. Minor bleeding
      1. Stop infusion
    4. Major bleeding
      1. Give FFP or PCC

Source

Tintinalli

Obtenido de «https://www.wikem.org/w/index.php?title=Hirudins&oldid=6339»