Baclofen toxicity

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Background

  • Indications include MS, muscle spasticity pain
  • GABAb receptor agonist

Toxicity

  • Adverse effects:
    • Drowziness, dizziness
    • N/V
    • Seizures, delirium, AMS
    • Bradycardia, hypotension, respiratory compromise

Management

  • Diagnosis of exclusion
  • Activated charcoal for recent ingestion
  • Supportive care:
    • IV fluids, respiratory care
    • Benzodiazepines for seizures
  • Hemodialysis for very severe toxicity


==References

  • Jung, M. “Baclofen Overdoses”. Maryland Poison Center, University of Maryland School of Pharmacy. www.mdpoison.com Accessed April 29th, 2014.
  • Nicola Y Leung, Ian M Whyte, Geoffrey K Isbister Baclofen overdose: defining the spectrum of toxicity. Emerg Med Australas: 2006, 18(1);77-82
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