Template:Warfarin Reversal

1. Stop warfarin
2. Give Vitamin K 5-10mg IV INR will decrease over 24-48 hours (small risk of anaphylaxis with IV Vitamin K)
3. Give 4 Factor Prothrombin Complex Concentrate (PCC)
4. If no PCC then give 2 unites Fresh Frozen Plasma
   • No benefit to combining PCC and FFP