Cefalonium

General

• Class: First-generation Cephalosporin antibiotic [en.wikipedia.org](https://en.wikipedia.org/wiki/Cefalonium)
• Chemical Structure: Contains Isonicotinamides, Thiophenes, and Pyridinium compounds [en.wikipedia.org](https://en.wikipedia.org/wiki/Cefalonium)
• Usage: Primarily used in veterinary medicine (specifically broadly used for mastitis in cattle and ophthalmic infections in biochemical research).

Dosing

Human

• Systemic: Not currently indicated for human clinical use.
• Note: Cefalonium is almost exclusively utilized in veterinary contexts, particularly for "dry cow" therapy (intramammary infusion) or topical ophthalmic preparations in animals.

Pharmacology

Mechanism of Action

Like other cephalosporins, Cefalonium is a bactericidal agent. It acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), disrupting the final transpeptidation step of peptidoglycan synthesis.

Chemical Data

• Type: Beta-lactam antibiotic
• Generation: First-generation
• Related Compounds: Structurally similar to other broad-spectrum cephalosporins containing thiophene rings.

Antibiotic Sensitivities

As a first-generation cephalosporin, Cefalonium exhibits activity primarily against Gram-positive bacteria and a limited range of Gram-negative bacteria.

Group	Organism	Sensitivity
Gram Positive	Staphylococcus aureus (MSSA)	S
	Streptococcus agalactiae	S
	Streptococcus dysgalactiae	S
Gram Negative	Escherichia coli	S/I
	Corynebacterium spp.	S

Key: S = Susceptible, I = Intermediate, R = Resistant

References

• Wikipedia contributors. "Cefalonium." Wikipedia, The Free Encyclopedia. [en.wikipedia.org](https://en.wikipedia.org/wiki/Cefalonium)