Neonatal HSV

Background

• Causative agent: HSV-1 or HSV-2
• Risk greatest under 3 weeks of age. Greatest risk factors is primary maternal HSV at delivery.

Conjunctival disease may be manifestation of SEM disease.

Risk Factors in Neonatal Fever

^Acyclovir if:

• HSV infection in baby or mother
• CSF pleocytoisis
• Concerning skin lesions
• Seizures
• Abnormal LFTs

Management

CNS or disseminated disease

• Acyclovir 20 mg/kg/dose Q8 IV x 21 days
• Add Trifluridine ophthalmic solution Q2 hours for ocular involvement
• Always refer to Ophthalmologist immediately

See Also

• Neonatal conjunctivitis
• Pediatric fever of uncertain source