Bone loss of spaceflight
Revisión del 20:58 3 feb 2025 de Ostermayer (discusión | contribs.) (Created page with "==Physiology== *Bone remodeling a continuous process where osteoclasts resorb old bone and osteoblasts form new bone. In microgravity, this balance is disrupted, leading to increased resorption and decreased formation. Weight-bearing bones, such as the hips and spine, are most affected due to the lack of gravitational stress. ==Overview== *In a six month’s duration, total body mineral density loss averages:<ref>Grigoriev AI, Oganov VS, Bakulin AV, Polyakov VV, Voroni...")
Physiology
- Bone remodeling a continuous process where osteoclasts resorb old bone and osteoblasts form new bone. In microgravity, this balance is disrupted, leading to increased resorption and decreased formation. Weight-bearing bones, such as the hips and spine, are most affected due to the lack of gravitational stress.
Overview
- In a six month’s duration, total body mineral density loss averages:[1]
- Pelvis - 12%
- Lumbar spine - 6%
- Femoral neck -8%
- There is significant variability with bone loss and most astronauts do no fully recover bone density[2]
References
- ↑ Grigoriev AI, Oganov VS, Bakulin AV, Polyakov VV, Voronin LI, Morgun VV, Schneider VS, Marachko LM, Novikov, VE, LeBlanc AD, Shackelford LC. Clinicophysiological evaluation of bone changes in cosmonauts after long-term space missions. Aerosp Environ Med (Russia) 1998; 32(1):21–25.
- ↑ Harm DL, Jennings RT, Meck JV, Powell MR, Putcha L, Sams CP, Schneider SM, Shackelford LC, Smith SM, Whitson PA. Genome and Hormones: Gender differences in physiology. Invited review: Gender issues related to spaceflight: A NASA Perspective. J Appl Physiol 2001; 91: 2374–2383