Template:Antibiotics Open Fracture
- NNT 16 to prevent early fracture site infection[1]
Grade I Fracture Options
- Cefazolin (Ancef) 2g IV three times daily
- Ciprofloxacin 400mg IV BID (avoid in pediatrics)
Grade II/III Fracture Options
- Add Gentamicin 300 mg (1-1.7mg/kg) IV to any of the Grade I regemins
- If concern for Clostridium then consider single drug regimen of Pipericillin/Tazobactam 4.5g (80mg/kg) IV three times daily
- ↑ TheNNT.com Early Antibiotic Use in Open Fractures http://www.thennt.com/nnt/antibiotics-for-open-fractures/