Sheehan's syndrome

Background

• Also known as postpartum hypopituitarism
• Caused by pituitary hypoperfusion and infarction usually in the setting of postpartum hemorrhage
• During pregnancy there is enlargement of the pituitary gland predisposing it to ischemia in low-flow states

Clinical Features

• Symptoms consistent with adrenal insufficiency, hypothyroidism and hypogonadism
  • Inability to lactate
  • Amenorrhea or oligomenorrhea
  • Fatigue
  • Cold intolerance
  • Lethargy
  • Weight loss

See Also

• Pregnancy