Drug fever

Background

Drug fever, or Drug-induced hyperthermia, is an adverse reaction to a drug in which the recipient of the drug develops a fever in direct response to receiving a specific drug. There are multiple mechanisms by which a drug can directly cause a fever response. These mechanisms include inducing a hyper-metabolic state, direct tissue damage and tissue necrosis, interference with peripheral vasodilation, activation of the cellular or humoral immune responses, or by acting as an endogenous pyrogen.