Background
- Cytokine release syndrome form of systemic inflammatory response syndrome from adverse effect of some monoclonal antibody drugs, as well as adoptive T-cell therapies
Clinical Features
- septic shock: hypotension, hypoxia, dyspnea, fever, tachycardia
- organ specific dysfunction: encephalopathy, coagulopathy, renal failure, CHF
Differential Diagnosis
Evaluation
Management
- treat for sepsis
- consider Tocilizumab (IL-6 receptor antagonist)
- corticosteroids for severe cases
Disposition
See Also
External Links
References
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003181/
