Template:Cholecystitis Antibiotics

Coverage is targeted at E. coli, Enterococcus, Bacteroides, and Clostridium (anerobic) Most often isolated organisms are Escherichia coli, Klebsiella pneumonia, and anaerobes, especially [[Bacteroides fragilis]]; pathogenicity of Enterococci remains unclear and specific coverage is not routinely suggested for community-acquired infections

Uncomplicated Cholecystitis

• Ertapenem 1g IV once daily OR
• Metronidazole 500mg IV q8hrs PLUS
  • Ciprofloxacin 400mg IV q12 hrs OR
  • Levofloxacin 750mg IV q24hrs OR
  • Ceftriaxone 1g IV q24hrs

Complicated

Complicated disease such as severe sepsis or hemodynamic instability

• Vancomycin 15-20mg/kg PLUS any of the following options

Options:

• Metronidazole 500mg IV q8hrs PLUS Ciprofloxacin 400mg IV q12hrs
• Piperacillin/Tazobactam 4.5g IV q8hrs
• Imipenem/Cilastin 500mg IV q6hrs
• Doripenem 500mg IV q8hrs
• Meropenem 1g IV q8hrs