Stone heart

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  • IV administration of intravenous calcium is thought to be contraindicated in patients with Digitalis Toxicity
  • In Stone Heart, calcium may theoretically cause an irreversible non-contractile state by impairing diastolic relaxation from calcium-troponin C binding in the presence of Na/K channel blockade by Digoxin
  • The excess calcium may also predispose to arrhythmias by adversely affecting re-polarization

Sources

  • Levine M, Nikkanen H, Pallin DJ. The effects of intravenous calcium in patients with digoxin toxicity. J Emerg Med. 2011 Jan;40(1):41-6.
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