Amyotrophic lateral sclerosis
Revisión del 03:59 26 mar 2014 de Timothydavie (discusión | contribs.)
Background
- Progressive muscle atrophy/weakness due to degeneration of upper and lower motor neurons
- Patients will rarely present to the ED undiagnosed
- Likely related to mutated superoxide dismutase (SOD1) gene
Clinical Features
- Acute respiratory failure
- Predicted by forced VC <25 mL/kg or 50% decrease from normal
- Aspiration pneumonia
- Trauma related to extremity weakness
Management
- Nebulized medications
- Steroids
- Antibiotics
- Assisted ventilation / intubation
See Also
Source
Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 7e (2010), Chapter 167. Chronic Neurologic Disorders