Trimethoprim-Sulfamethoxazole DS

General

• Type: Sulfonamide
• Dosage Forms: 160/800
• Common Trade Names: Bactrim DS

Adult Dosing

General

1 tab (160mg TMP) PO Q12h

PCP Prophylaxis

80-160mg TMP PO daily

PCP Treatment

15-20 mg/kg/day TMP PO divided q6-8h x 21 days

Pediatric Dosing

General (>2mo)

• Mild-mod infection
  • 4-5 mg/kg TMP PO q12hr
• Severe infection
  • 15-20 mg/kg/dy TMP PO divided q6-8h

Contraindications

• Allergy to class/drug

Pharmacology

• Half-life: 6-12h (20-50h ESRD)
• Metabolism:
• Excretion:
• Mechanism of Action: Bactericidal

Pregnancy/Lactation

• Pregnancy:
• Lactation:

See Also

• Antibiotics