Raltegravir

Administration

• Type: Antiretroviral, Integrase inhibitor
• Dosage Forms: 400 mg, 600 mg tablet
• Routes of Administration: PO
• Common Trade Names: Isentress

Adult Dosing

• Treatment-naive:

Special Populations

• Pregnancy Rating: C
• Lactation risk: Unknown

Renal Dosing

• • Mild to Moderate renal disease: No dosage adjustment necessary
  • ESRD on HD: Dose after dialysis on dialysis days

Hepatic Dosing

No dosage adjustment necessary

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• Stevens-Johnson Syndrome
• Anaphylaxis
• Myopathy/Rhabdomyolysis

Common

• Hepatic- increased transaminases

Pharmacology

• Half-life:
• Metabolism:
• Excretion: