Drug induced aseptic meningitis

Background

• Abbreviation: DIAM
• Two proposed mechanisms
  • Direct meningeal irritation by intrathecal drug
  • Hypersensitivity reaction to drug (type III and IV)

Causes

• NSAIDs
• Antibiotics
  • Sulfamethizole
  • TMP-SMX
  • Isoniazid
  • Ciprofloxacin
  • Penicillin
  • Metronidazole
  • Cephalosporin
  • Pyrazinamide