Ceftolozane/tazobactam

General

  • Type: Antibiotic (cephalosporin/beta-lactamase inhibitor combination)
  • Dosage Forms: IV
  • Common Trade Names: Zerbaxa

Adult Dosing

  • 1.5 grams (1gm ceftolozane/0.5gm tazobactam) IV q8H

Pediatric Dosing

N/A

Special Populations

  • Pregnancy Rating: B
  • Lactation:
  • Renal Dosing
    • Adult - 750mg IV q8hr for moderate renal impairment, 375mg IV q8hr for severe impairment
    • Pediatric - N/A
  • Hepatic Dosing
    • Adult - N/A
    • Pediatric - N/A

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life:
  • Metabolism: N/A
  • Excretion: Renal (100%)
  • Mechanism of Action: