Glucarpidase

Administration

• Dosage Forms: 1000 units/vial
• Routes of Administration: IV
• Common Trade Names: Voraxaze

Adult Dosing

• Methotrexate toxicity
  • 50 units/kg IV x1
    • For patients with mod-severe renal impairment

Pediatric Dosing

• Methotrexate toxicity
  • 50 units/kg IV x1
    • For patients with mod-severe renal impairment

Special Populations

• Pregnancy Rating: C; Benefits outweigh risks during pregnancy
• Lactation risk: L3; Safety unknown

Renal Dosing

• Adult: No adjustment
• Pediatric: Not defined

Hepatic Dosing

• Adult: No adjustment
• Pediatric: Not defined

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• Anaphylaxis

Common

• Paresthesia
• Flushing
• Nausea/Vomiting

Pharmacology

• Half-life: 5.6 hr, 8.2 hr (Crcl < 30)
• Metabolism: Unknown
• Excretion: Unknown

Mechanism of Action

• Hydrolyzes carboxyl-terminal glutamate, converting methotrexate to inactive metabolisms.

See Also

Methotrexate toxicity