Dicyclomine

General

• Type: antispasmodic, antimuscarinic
• Indication: traditionally for treatment of irritable bowel syndrome
• Dosage Forms: PO, IM
  • DO NOT GIVE IV
• Common Trade Names: Bentyl®

Adult Dosing

• 10-20 mg PO or IM q6 prn

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• Anticholinergic toxicity

Pharmacology

• Half-life: ~2 hours
• Excretion: Urine ~80%, ~10% feces
• Mechanism of Action: antimuscarinic, direct smooth muscle antagonism of bradykinin and histamine-induced muscular spasms, which atropine does not

Sources

• McAuley DF. GlobarlRPh Inc. ANTISPASMOTICS - Bowel spasm / cramping / IBS / Hypermotility. Last updated 12/04/2016. http://www.globalrph.com/antispasmotic.htm#Dicyclomine_.