Fluticasone propionate

Administration

• Type: Corticosteroid
• Dosage Forms:
• Routes of Administration: Inhalation, intranasal, topical
• Common Trade Names: Flonase

Adult Dosing

• Intranasal: 2 sprays/nostril daily
• Aerosol: 88-880 mcg BID
• Powder (inhaled): 100-1000 mcg BID
• Topical application: 1-2 times daily

Special Populations

• Pregnancy Rating: C
• Lactation risk: Infant risk cannot be ruled out
• Renal dosing: no adjustment
• Hepatic dosing: no adjustment

Contraindications

• Allergy to class/drug
• Severe hypersensitivity to milk proteins
• Primary treatment of acute asthma exacerbation

Adverse Reactions

Serious

• Secondary hypocortisolism
• Glaucoma, elevated ICP
• Pneumonia

Common

• Oral or esophageal candidiasis
• Nausea/vomiting
• Headache
• Osteoporosis
• Cough, URI symptoms
• Epistaxis

Pharmacology

• Half-life: 3.2-11.2h
• Metabolism: Hepatic CYP3A4
• Excretion: Fecal

Mechanism of Action

• Glucocorticoid, anti-inflammatory

See Also

• Corticosteroids
• Inhaled steroids
• Topical steroids