Aripiprazole

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Administration

  • Type: Atypical antipsychotic
  • Dosage Forms:
  • Routes of Administration: PO, IM depot
  • Common Trade Names: Abilify

Adult Dosing

  • 2-30 mg PO daily

Pediatric Dosing

  • > 6yo: 2-30 mg PO daily (slower titration up)

Special Populations

  • Pregnancy Rating: C
  • Lactation risk: Infant risk cannot be ruled out
  • Concomitant use of CYP3A4 or CYP2D6 inhibitors: reduce dose
  • Concomitant use of CYP3A4 inducers: increase dose
  • Renal dosing: no adjustment
  • Hepatic dosing: no adjustment

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • Cardiac arrest, cardiac failure, prolonged QT, MI
  • Neuroleptic malignant syndrome, hyperthermia, rhabdomyolysis
  • Seizure, stroke
  • Tardive dyskinesia
  • Agranulocytosis, leukopenia
  • Angioedema
  • Pancreatitis
  • DKA
  • Suicidal behavior

Common

  • Somnolence, dizziness, akathisia, anxiety, insomnia, headache
  • Extrapyramidal symptoms, tremor
  • Nausea, vomiting, constipation
  • Weight gain

Pharmacology

  • Half-life: ~75 hours
  • Metabolism: Hepatic via CYP2D6 and CYP3A4
  • Excretion: Mostly fecal

Mechanism of Action

  • Not well understood. D2 and HT2A antagonist, D3 and 5HT1A partial agonist

Comments

See Also

References

Obtenido de «https://www.wikem.org/w/index.php?title=Aripiprazole&oldid=104648»