Eosinophilia

Background

• Defined usually as peripheral eosinophil count >0.5 x 10⁹/L
• Eosinophils normally comprise <7% of total WBC count

Differential Diagnosis

• Allergic reaction or other hypersensitivity/atopic state
  • Urticaria, atopic dermatitis, asthma, drug reaction/hypersensitivity
• DRESS syndrome, drug-induced
• Parasitic infection
• Coccidioidomycosis and other fungal infections
• Malignancy (e.g. lymphoma, eosinophilic leukemia)
• Skin disorders (e.g. bullous pemphigoid, dermatitis herpetiformis)
• Adrenal insufficiency
• Connective tissue disease (e.g. Churg-Strauss syndrome)
• Interstitial nephritis
• Arsenic, gold toxicity

Evaluation

• CBC with differential

Management

• Directed at underlying cause

See Also

• Leukocytosis