Vecuronium

General

• Type: Neuromuscular blocker, nondepolarizing, fast
• Dosage Forms: IV
• Common Trade Names: Norcuron

Adult Dosing

• Not recommended for RSI
• 0.15mg/kg IV based on ideal body weight, can prime with 0.01mg/kg IV

Pediatric Dosing

• Not recommended for RSI

Special Populations

• Pregnancy Rating: C
• Lactation: Infant risk cannot be ruled out
• Renal Dosing
  • Adult
  • Pediatric
• Hepatic Dosing
  • Adult
  • Pediatric

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• Anaphylaxis

Pharmacology

• Half-life: Varies, from 30-60 minutes
• Metabolism: Hepatic
• Excretion: Renal
• Mechanism of Action: Non-depolarizing neuromuscular blocking agent. Long duration with slow onset. Competes for cholinergic receptors at the motor end-plate. Acetylcholinesterase inhibitors like those found in organophosphates antagonize this action

Indications by Condition

The following table is automatically generated from disease/condition pages across WikEM.

	Indication	Dose	Context	Route	Population
Rapid sequence intubation#Vecuronium Paralytic Adult	Rapid sequence intubation	0.1 mg/kg	Paralytic	IV	Adult

See Also

• Critical care quick reference
• Reversal agent: Sugammadex

References

Micromedex