Permethrin
Administration
- Type: Pediculicide
- Dosage Forms: Cream or lotion
- Routes of Administration: Topical
- Common Trade Names: Nix, Elimite
Adult Dosing
Indications by Disease
| Disease | Dose | Context |
|---|---|---|
| Scabies | 5% cream neck down leave 8-12hrs repeat 1-2wks | First line adults |
Pediatric Dosing
Indications by Disease
| Disease | Dose | Context |
|---|---|---|
| Scabies | 5% cream, apply head to toe (avoid mucous membranes), leave 8-12hrs, wash off; repeat in 1-2 weeks | Pediatric (>2 months) |
Special Populations
- Pregnancy Rating: B
- Lactation risk: Infant risk minimal
- Renal dosing: not defined
- Hepatic dosing: not defined
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Serious reactions are rare
Common
- Rash, erythema, pruritus, burning/stinging sensation
- Swelling
Pharmacology
- Topical: <2% absorbed
- Half-life:
- Metabolism:
- Excretion: Renal
Mechanism of Action
- Disrupts neuronal sodium channel current in louse/mite, leading to delayed repolarization of nerve and subsequent paralysis/death