Fluconazole

General

• Type: Antifungal
• Dosage Forms: IV; PO
• Common Trade Names: Diflucan

Adult Dosing

General

Candidiasis, oropharyngeal/esophageal

• 100mg PO qday x 2 week to prevent relapse

Candida vaginitis

• Uncomplicated: 150mg PO x 1

Pediatric Dosing

Candidiasis, oropharyngeal/esophageal:

• > 14 days old: 6mg/kg PO x 1, then 3mg/kg q24h x 7-14 days, max: 100mg/day

Tinea Capitis: > 14 days old: 3-6mg/kg PO q24h x 6 weeks

Special Populations

• Pregnancy Rating: D
• Lactation Risk Categories: safety unknown
• Renal Dosing
  • Adult:CrCrl < 50, give usual loading dose x 1 then decrease dose 50%
  • Pediatric: CrCrl < 50, give usual loading dose x 1 then decrease dose 50%
• Hepatic Dosing
  • Adult: not defined
  • Pediatric: not defined

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• hepatotoxicity
• seizures
• leukopenia
• thrombocytopenia
• anaphylaxis
• steven-johnson syndrome
• QT prolongation

Common

• Nausea
• Rash
• Headache
• vomiting
• diarrhea
• Transaminitis

Pharmacology

• Half-life: 30 hour
• Metabolism: Liver
• Excretion: urine
• Mechanism of Action: inhibits cytochrome p450 and sterol c-14 alpha-demethylation