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| ==Background==
| | #REDIRECT [[Isopropyl Alcohol Toxicity]] |
| *Main component of rubbing alcohol
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| *Hallmark is osmolar gap without acidosis
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| **Metabolized to acetone, not to an acid
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| ***Takes 30-60min for acetone to appear in blood, 3hr to appear in urine
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| ==Clinical Features==
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| *GI
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| **N/V / abd pain / hemorrhagic gastritis
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| *CNS depression
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| **Similar to ETOH intoxication, but longer-lasting
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| *Respiratory depression
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| *Hypotension
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| *Hypoglycemia (in malnourished pts)
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| ==Diagnosis==
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| *Ketonuria/ketonemia
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| *No acidosis
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| *Elevated osmolar gap
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| ==Treatment==
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| *GI decontamination
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| **Activated charcoal ineffective (absorbed too quickly)
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| *Airway
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| **Mechanical ventilation may be necessary
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| *Hypotension
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| **Usually responsive to IVF; pressors may be necessary
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| *Fomepizole
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| **Unnecessary
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| ***Metabolite, acetone, is no more toxic than the parent compound
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| ***Use may lead to prolonged CNS toxicity
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| *Hemodialysis
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| **Consider for:
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| ***Hypotension refractory to conventional therapy
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| ***Isopropanol level >400
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| ==Disposition==
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| *Consider d/c if asymptomatic x4-6hr
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| ==Source==
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| *Tintinalli
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| [[Category:Tox]] | | [[Category:Tox]] |
