Diferencia entre revisiones de «Pyridoxine»
| Línea 6: | Línea 6: | ||
==Adult Dosing== | ==Adult Dosing== | ||
*Seizures associated with overdose of [[INH]] or ingestion of [[gyromitra]] mushrooms <ref> Berger KJ, Guss DA. Mycotoxins revisited: Part II. J Emerg Med. 2005;28(2):175. </ref> <ref>Howland MA, “Antidotes in Depth: Pyridoxine,” Goldfrank's Toxicologic Emergencies, 10th ed, Flomenbaum NE, Goldfrank LR, Hoffman RS, et al, eds, New York, NY: McGraw-Hill Companies, Inc, 2015, 872-5.</ref> | *Seizures associated with overdose of [[INH]] or ingestion of [[gyromitra]] mushrooms <ref> Berger KJ, Guss DA. Mycotoxins revisited: Part II. J Emerg Med. 2005;28(2):175. </ref> <ref>Howland MA, “Antidotes in Depth: Pyridoxine,” Goldfrank's Toxicologic Emergencies, 10th ed, Flomenbaum NE, Goldfrank LR, Hoffman RS, et al, eds, New York, NY: McGraw-Hill Companies, Inc, 2015, 872-5.</ref> | ||
**Known | **Known quantity ingested: Give IV pyridoxine 1:1 with amount ingested, up to 5 grams | ||
**Unknown quantity ingested: 5 grams | **Unknown quantity ingested: 5 grams | ||
**IV Infusion rate is 0.5 g/min until the seizures stop or the maximum dose is reached. Remainder of dose infused over 4 to 6 hours | **IV Infusion rate is 0.5 g/min until the seizures stop or the maximum dose is reached. Remainder of dose infused over 4 to 6 hours | ||
Revisión del 04:33 9 jun 2016
Administration
- Type: Water soluble vitamin
- Routes of Administration: Oral, IV/IM
- Common Trade Names: Vitamin B6
Adult Dosing
- Seizures associated with overdose of INH or ingestion of gyromitra mushrooms [1] [2]
- Known quantity ingested: Give IV pyridoxine 1:1 with amount ingested, up to 5 grams
- Unknown quantity ingested: 5 grams
- IV Infusion rate is 0.5 g/min until the seizures stop or the maximum dose is reached. Remainder of dose infused over 4 to 6 hours
Pediatric Dosing
- Seizures associated with overdose of INH
- Known quantity ingested: Give IV pyridoxine 1:1 with amount ingested, up to 5 grams
- Unknown quantity ingested: 1 gm/kg up to 5 gm (adult dose)
- Gyomitra ingestion
- 70 mg/kg initial dose
Special Populations
Renal Dosing
- Adult:
- Pediatric:
Hepatic Dosing
- Adult:
- Pediatric:
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion: