Diferencia entre revisiones de «Chloral hydrate»
(chloral sx) |
Sin resumen de edición |
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| Línea 27: | Línea 27: | ||
*CV | *CV | ||
**Hypotension | **Hypotension | ||
* | *Myocardial depression | ||
**Tachydysrhythmias | **Tachydysrhythmias | ||
***Catecholamine hypersensitivity: Sinus tachycardia, PVCs, VT, VF, Torsades | ***Catecholamine hypersensitivity: Sinus tachycardia, PVCs, VT, VF, Torsades | ||
Revisión del 15:28 15 feb 2016
Background
- Sedative-hypnotic used for insomnia
- Binds GABA-A receptor
- Active metabolite trichloroethanol (TCE)
Pharmacokinetics
- Onset: 30-60 min
- Duration: 4-8 hr
- Half-Life: 5 mins (for chloral hydrate)
- 8-11 hr (active metabolite)
- Metabolism: Hepatic metabolism
- Excretion: Mostly in urine; some feces
- Potential toxic dose
- <6 years old: 50 mg/kg
- Adults: 3-10g
Clinical Features
- Similar to barbiturates and hydrocarbons
- Neuro
- Sedation, ataxia, coma
- GI
- Erosive gastritis, UGIB, strictures
- Hepatitis
- Breath smells like pears
- Renal
- Nephrotixicity, proteinuria
- CV
- Hypotension
- Myocardial depression
- Tachydysrhythmias
- Catecholamine hypersensitivity: Sinus tachycardia, PVCs, VT, VF, Torsades
- Tachydysrhythmias
- Resp
- Resp depression, airway obstruction (from muscle relaxation)
- Aspiration pneumonitis