Diferencia entre revisiones de «Chloral hydrate»
(chloral) |
(chloral pharm) |
||
| Línea 7: | Línea 7: | ||
*Onset: 30-60 min | *Onset: 30-60 min | ||
*Duration: 4-8 hr | *Duration: 4-8 hr | ||
*Half-Life: 8-11 hr (active metabolite) | *Half-Life: 5 mins (for chloral hydrate) | ||
**8-11 hr (active metabolite) | |||
*Metabolism: Hepatic metabolism | |||
*Excretion: Mostly in urine; some feces | *Excretion: Mostly in urine; some feces | ||
*Potential toxic dose | *Potential toxic dose | ||
Revisión del 15:23 15 feb 2016
Background
- Sedative-hypnotic used for insomnia
- Binds GABA-A receptor
- Active metabolite trichloroethanol (TCE)
Pharmacokinetics
- Onset: 30-60 min
- Duration: 4-8 hr
- Half-Life: 5 mins (for chloral hydrate)
- 8-11 hr (active metabolite)
- Metabolism: Hepatic metabolism
- Excretion: Mostly in urine; some feces
- Potential toxic dose
- <6 years old: 50 mg/kg
- Adults: 3-10g