Diferencia entre revisiones de «Ivermectin»
| Línea 5: | Línea 5: | ||
==Adult Dosing== | ==Adult Dosing== | ||
===[[Strongyloidiasis]]=== | |||
*0.2 mg/kg PO x1 | |||
===[[Onchocerciasis]]=== | |||
*0.15 mg/kg PO x1 | |||
===[[Scabies]], non-crusted=== | |||
*0.2 mg/kg PO x1 | |||
===[[Scabies]], crusted=== | |||
*0.2 mg/kg PO x1 on days 1,2,8,9,15 | |||
===[[Pediculosis capitis]]=== | |||
*0.2 mg/kg pO q10 days x2 doses | |||
===[[Pediculosis corporis]]=== | |||
*12 mg PO q7 days x3 doses | |||
===[[Pediculosis pubis]]=== | |||
*0.25 mg/kg PO q2wk x2 doses | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
Revisión del 12:32 26 ago 2015
General
- Type: antiparasitic
- Dosage Forms: 3
- Common Trade Names: Stromectol
Adult Dosing
Strongyloidiasis
- 0.2 mg/kg PO x1
Onchocerciasis
- 0.15 mg/kg PO x1
Scabies, non-crusted
- 0.2 mg/kg PO x1
Scabies, crusted
- 0.2 mg/kg PO x1 on days 1,2,8,9,15
Pediculosis capitis
- 0.2 mg/kg pO q10 days x2 doses
Pediculosis corporis
- 12 mg PO q7 days x3 doses
Pediculosis pubis
- 0.25 mg/kg PO q2wk x2 doses
Pediatric Dosing
Special Populations
- Pregnancy Rating: C
- Lactation: Safety Unknown
- Renal Dosing- not defined
- Hepatic Dosing- not defined
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- hypotension, orthostatic
- tachycardia
- seizures
- Stevens-Johnson syndrome
- toxic epidermal necrolysis
- asthma exacerbation
- vision loss
- conjunctival hemorrhage
- hepatitis
Common
- pruritus
- rash
- fever
- edema
- lymphadenopathy
- headache
- myalgia
- dizziness
- tachycardia
- abnormal eye sensation
- limbitis
- conjunctivitis
- ocular inflammation
- hypotension, orthostatic
- ALT, AST elevated
- eosinophilia
Pharmacology
- Half-life: 18h
- Metabolism: liver, CYP450: unknown
- Excretion: feces primarily, urine < 1%
- Mechanism of Action: increases invertebrate nerve and muscle cell membrane permeability by binding to chloride ion channels, resulting in paralysis and death of parasite