Diferencia entre revisiones de «Ivermectin»
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==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 18h | ||
*Metabolism: | *Metabolism: liver, CYP450: unknown | ||
*Excretion: | *Excretion: feces primarily, urine < 1% | ||
*Mechanism of Action: | *Mechanism of Action: increases invertebrate nerve and muscle cell membrane permeability by binding to chloride ion channels, resulting in paralysis and death of parasite | ||
==See Also== | ==See Also== | ||
Revisión del 21:14 30 jun 2015
General
- Type: antiparasitic
- Dosage Forms: 3
- Common Trade Names: Stromectol
Adult Dosing
strongyloidiasis: 0.2 mg/kg PO x1
onchocerciasis: 0.15 mg/kg PO x1
scabies, non-crusted: 0.2 mg/kg PO x1
scabies, crusted: 0.2 mg/kg PO x1 on days 1,2,8,9,15
pediculosis capitis: 0.2 mg/kg pO q10 days x2 doses
pediculosis corporis: 12 mg PO q7 days x3 doses
pediculosis pubis: 0.25 mg/kg PO q2wk x2 doses
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- hypotension, orthostatic
- tachycardia
- seizures
- Stevens-Johnson syndrome
- toxic epidermal necrolysis
- asthma exacerbation
- vision loss
- conjunctival hemorrhage
- hepatitis
Common
- pruritus
- rash
- fever
- edema
- lymphadenopathy
- headache
- myalgia
- dizziness
- tachycardia
- abnormal eye sensation
- limbitis
- conjunctivitis
- ocular inflammation
- hypotension, orthostatic
- ALT, AST elevated
- eosinophilia
Pharmacology
- Half-life: 18h
- Metabolism: liver, CYP450: unknown
- Excretion: feces primarily, urine < 1%
- Mechanism of Action: increases invertebrate nerve and muscle cell membrane permeability by binding to chloride ion channels, resulting in paralysis and death of parasite