Emergency contraception

Treatment

Progestin-Only Regimen

1. First dose within 48 hours after unprotected intercourse followed by second dose 12 hours later
   1. may take both at once
2. Relative risk reduction of pregnancy = 89% (1% with vs 8% without)
3. Side effects
   1. Nausea (23%)
   2. Vomiting (6%)
4. no teratogenisis
5. FDA approved regimens:
   1. Plan B (marketed specifically for emergency contraception) - 1 pill (0.75 mg levonorgestrel) per dose

Yuzpe Regimen

(combination OCPs)

1. First dose within 72 hours after unprotected intercourse followed by second dose 12 hours later
2. May be given up to 120 hours later (but efficacy reduced)
3. Reduces risk of pregnancy by 75% (2% with vs 8% without)
4. Side effects
   1. Nausea (50%)
   2. Vomiting (20%)
5. Safety
   1. No teratogenic effect
6. Contraindications
   1. Pregnancy
7. FDA approved regimens:
   1. Ovral, Ogestrel - 2 pills (100 ug ethiny estradiol/0.5 mg levonorgestrel) per dose
   2. Alesse, Aviane, Levlite - 5 pills (100 ug ethiny estradiol/0.5 mg levonorgestrel) per dose
   3. Levlen, Levora, Lo/Ovral, Low-Ogestrel - 4 pills (120 ug ethiny estradiol/0.6 mg levonorgestrel) per dose
   4. Triphasil, Tri-Levlen, Trivora - 4 pills (120 ug ethiny estradiol/0.5 mg levonorgestrel) per dose

Source

7/09 PANI