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==Conclusion== | ==Conclusion== | ||
'''Patients with ischemic stroke who received IV ateplase 3 to 4.5 hours after symptom onset had significant improvement in clinical outcomes. However, ateplase was associated with more frequent symptomatic intracranial hemorrhage.''' | |||
==Major Points== | ==Major Points== | ||
Revisión del 06:10 18 oct 2014
incomplete Journal Club Article
Hacke W, et al. "Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke". The New England Journal of Medicine. 2008. 359(13):1317-1329.
PubMed Full text PDF
PubMed Full text PDF
Clinical Question
Is ateplase safe and effective for ischemic stroke patients when administered 3 to 4.5 hours after the onset of symptoms?
Conclusion
Patients with ischemic stroke who received IV ateplase 3 to 4.5 hours after symptom onset had significant improvement in clinical outcomes. However, ateplase was associated with more frequent symptomatic intracranial hemorrhage.
Major Points
Study Design
Population
Patient Demographics
Inclusion Criteria
Exclusion Criteria
Interventions
Outcomes
Primary Outcome
Secondary Outcomes
Subgroup analysis
Criticisms & Further Discussion
Funding
Sources
[[Category:Neuro]