Diferencia entre revisiones de «Cytokine release syndrome»
(Created page with "==Background== *Cytokine release syndrome form of systemic inflammatory response syndrome from adverse effect of some monoclonal antibody drugs, as well as adoptive T-cell the...") |
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==Evaluation== | ==Evaluation== | ||
*cytopenias, elevated creatinine and liver enzymes, deranged coagulation parameters, high CRP | |||
==Management== | ==Management== | ||
Revisión del 16:31 21 ago 2019
Background
- Cytokine release syndrome form of systemic inflammatory response syndrome from adverse effect of some monoclonal antibody drugs, as well as adoptive T-cell therapies
Clinical Features
- septic shock: hypotension, hypoxia, dyspnea, fever, tachycardia
- organ specific dysfunction: encephalopathy, coagulopathy, renal failure, CHF
Differential Diagnosis
Evaluation
- cytopenias, elevated creatinine and liver enzymes, deranged coagulation parameters, high CRP
Management
- treat for sepsis
- consider Tocilizumab (IL-6 receptor antagonist)
- corticosteroids for severe cases
Disposition
- admit