Diferencia entre revisiones de «Raltegravir»
Sin resumen de edición |
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| Línea 19: | Línea 19: | ||
===Renal Dosing=== | ===Renal Dosing=== | ||
*Mild to Moderate renal disease: No dosage adjustment necessary | |||
*ESRD on HD: Dose after dialysis on dialysis days | |||
===Hepatic Dosing=== | ===Hepatic Dosing=== | ||
No dosage adjustment necessary | No dosage adjustment necessary | ||
Revisión del 19:52 29 mar 2018
Administration
- Type: Antiretroviral, Integrase inhibitor
- Dosage Forms: 400 mg, 600 mg tablet
- Routes of Administration: PO
- Common Trade Names: Isentress
Adult Dosing
Recommended as part of a regimen including Tenofovir plus Emtricitabine or Lamivudine
- Treatment-naive: 400 mg BID or 1200 mg daily
- Treatment-experienced: 400 mg BID
Pediatric Dosing
Oral suspension (10 mg/mL): 6 mg/kg/dose BID
- Maximum dose: 100 mg/dose
Special Populations
- Pregnancy Rating: C
- Lactation risk: Unknown
Renal Dosing
- Mild to Moderate renal disease: No dosage adjustment necessary
- ESRD on HD: Dose after dialysis on dialysis days
Hepatic Dosing
No dosage adjustment necessary
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Stevens-Johnson Syndrome
- Anaphylaxis
- Myopathy/Rhabdomyolysis
Common
- Hepatic- increased transaminases
Pharmacology
- Half-life: 9 hours
- Metabolism: Hepatic glucuronidation
- Excretion: Renal
Mechanism of Action
- Reverse transcriptase inhibitor