Diferencia entre revisiones de «Tamsulosin»
(Text replacement - "Alpha" to "α") |
(Text replacement - "α blocker" to "α-blocker") |
||
| Línea 1: | Línea 1: | ||
==Administration== | ==Administration== | ||
*Type: α blocker | *Type: α-blocker | ||
*Dosage Forms: | *Dosage Forms: | ||
*Routes of Administration: oral | *Routes of Administration: oral | ||
Revisión del 00:08 2 ago 2017
Administration
- Type: α-blocker
- Dosage Forms:
- Routes of Administration: oral
- Common Trade Names: Flomax
Adult Dosing
- 0.4mg PO once daily or nightly
Urolithiasis
- 0.4mg PO QHS until stone expulsion
Pediatric Dosing
Safety/efficacy not established
Special Populations
- Pregnancy Rating: B
- Lactation risk: Infant risk cannot be ruled out
Renal Dosing
- Adult: No adjustment for CrCl >10
Hepatic Dosing
- Adult: No adjustment
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Retinal detachment
- Priapism
Common
- Headache, dizziness, insomnia, somnolence
- Abnormal ejaculation
- Rhinitis
- Back pain
Pharmacology
- Half-life: 9-15h
- Metabolism: CYP3A4 and CYP2D6
- Excretion: Mostly renal
Mechanism of Action
- α-1A antagonist→ smooth muscle relaxation in bladder neck, prostate, urethra→ increased urine flow rate