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| ==Background==
| | #REDIRECT[[Intravascular hemolytic transfusion reaction]] |
| *Occurs due to ABO incompatibility
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| *High mortality. 1:30 may die.
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| ==Clinical Features==
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| *High grade fever, back/flank pain, headache, hypotension, dyspnea, pulmonary edema, bleeding, renal failure, hematuria
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| *Sick and shocky
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| ==Differential Diagnosis==
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| {{Transfusion reaction types}}
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| {{Acute Allergic DDX}}
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| ==Evaluation==
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| *Labs consistent with hemolysis
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| *Send off coombs test/direct antiglobin test
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| **Coomb's reagent binds RBCs with Ab on them
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| [[File:Coombs.png|thumbnail]] | |
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| ==Management==
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| *Stop transfusion
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| *Replace all tubing
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| **Risk of death is proportional to amount of incompatible blood received
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| *Maintain urine output with IVF (1-2 mL/kg/hr), [[mannitol]], and [[furosemide]] as needed
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| *Treat shock with volume and [[vasopressors]]
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| *Treat coagulopathy with [[FFP]]
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| ==Disposition==
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| ==See Also==
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| *[[Transfusion reaction]]
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| ==External Links==
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| ==References==
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| <references/>
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| [[Category:Heme/Onc]]
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