Diferencia entre revisiones de «Hemochromatosis»
(Created page with "==Background== *accumulation of iron in the body *most commonly due to hereditary hemochromatosis (HHC) and transfusional iron overload **Hereditary hemochromatosis most commo...") |
Sin resumen de edición |
||
| Línea 1: | Línea 1: | ||
==Background== | ==Background== | ||
* | *Accumulation of iron in the body | ||
* | *Most commonly due to hereditary hemochromatosis (HHC) or iron overload from [[transfusion]] | ||
**Hereditary hemochromatosis most common in people of Celtic ancestry | **Hereditary hemochromatosis most common in people of Celtic ancestry | ||
*AKA "bronze diabetes" | *AKA "bronze diabetes" | ||
| Línea 18: | Línea 18: | ||
==Management== | ==Management== | ||
*Phlebotomy | *Phlebotomy | ||
*Chelation with deferoxamine | *Chelation with [[deferoxamine]] | ||
==Disposition== | ==Disposition== | ||
| Línea 27: | Línea 27: | ||
==References== | ==References== | ||
<references/> | <references/> | ||
[[Category:Heme/Onc]] | |||
Revisión del 18:02 27 mar 2017
Background
- Accumulation of iron in the body
- Most commonly due to hereditary hemochromatosis (HHC) or iron overload from transfusion
- Hereditary hemochromatosis most common in people of Celtic ancestry
- AKA "bronze diabetes"
Clinical Features
- Cirrhosis
- Diabetes due to iron deposition in pancreatic beta cells
- Cardiomyopathy
- Arthritis: knuckles of the second and third fingers most common
- Bronzing of the skin
Differential Diagnosis
Evaluation
- Serum ferritin:
- >300 ng/mL in males and postmenopausal women
- >150 - 200 ng/mL in premenopausal women
Management
- Phlebotomy
- Chelation with deferoxamine