Diferencia entre revisiones de «Carbamazepine toxicity»
(Text replacement - "==Diagnosis==" to "==Evaluation==") |
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**[[QT Prolongation]] | **[[QT Prolongation]] | ||
== | ==Evaluation== | ||
*Levels do not accurately correlate with clinical severity | *Levels do not accurately correlate with clinical severity | ||
Revisión del 19:51 21 jul 2016
Background
- Has anticholinergic and antiepileptic effects
- Therapeutic concentration: 4-12
Clinical Features
- May be delayed and follow crescendo-decrescendo course (due to delayed GI motility)
- CNS
- Ataxia
- Nystagmus
- Coma
- Anticholinergic Toxicity
- CV
- Dysrhythmias are rare but may occur
- Wide QRS
- QT Prolongation
Evaluation
- Levels do not accurately correlate with clinical severity
Management
- GI detox
- Activated Charcoal (if presents within 1hr of ingestion)
- Dialysis is effective (if needed)
Disposition
- Consider discharge for patient with decreasing levels (measured few hrs apart) and is asymptomatic